Molecular biology of the feline immunodeficiency virus auxiliary genes

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Molecular biology of the feline immunodeficiency virus auxiliary genes.

Introduction Feline immunodeficiency virus (FIV) causes a slowly progressive multiorgan disease in infected cats and shows considerable pathogenic similarities to the human immunodeficiency virus type I (HIV-1i), the causative agent of AIDS (Miyazawa & Mikami, 1993; Pedersen et al., 1987; Yamamoto et al., 1988). It is therefore considered a useful small-animal model for HIV-l-induced AIDS studi...

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The Molecular Biology of Feline Immunodeficiency Virus (FIV)

Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increase in interest in FIV, in part to exploit this, but also because of the potenti...

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Infection of domestic cats with feline immunodeficiency virus (FIV) is an important model system for studying human immunodeficiency virus type 1 (HIV-1) infection due to numerous similarities in pathogenesis induced by these two lentiviruses. However, many molecular aspects of FIV replication remain poorly understood. It is well established that retroviruses use short peptide motifs in Gag, kn...

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Feline immunodeficiency virus (FIV) is a T-lymphotropic retrovirus associated with immunodeficiency and opportunistic infections in cats. The discovery of FIV provides an opportunity for the development of a small animal model for AIDS. To initiate the molecular and biological characterization of FIV, cDNA clones were synthesized and used to isolate a proviral clone of FIV. Molecular cross-hybr...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1996

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-77-8-1611